This topical medication contains one of the most effective antibiotics known for acne breakouts. Trimethoprim sulfamethoxazole is an antibiotic typically taken by mouth, but can be applied topically using our SMX Tincture, clearing skin of acne-causing bacteria. With regular use, acne breakouts are noticeably reduced, resulting in clearer skin. Apply as directed with a cotton ball to affected areas after washing. SMX should not be used by patients allergic to sulfa medications.